Embryo Genetic Testing (PGD/PGS)
For patients that are interested in the genetic viability of embryo prior to implantation, MCRM offers patients genetic testing. This testing determines whether or not an embryo(s) is genetically “normal” by investigating the DNA within a particular embryo. This may be done through one of two processes:
- Single-Gene Preimplantation Genetic Diagnosis (PGD)
- Preimplantation Genetic Screening (PGS) with Next Generation Sequencing (NGS)
PGD analysis is where a few cells are extracted from the embryo and analyzed for a single, specific gene disorder. This process is usually used for patients who have a history of genetic abnormalities. The draw back to these types of tests is that it does not look at the entire set of chromosomes for the specific embryo.
PGS is the genetic testing where by, similar to PGD, a few cells are biopsied from a particular embryo. The DNA is extracted and then analyzed. PGS looks at the entire set of chromosomes to ensure that there are the correct number of chromosomes. Along with the correct number of chromosomes PGS also ensures there is the correct balance of chromosome sets; ensuring the patients the genetic integrity of the specific embryo.
A Patient Who Might Consider Genetic Testing:
- Known Carrier of Genetic Mutation
A couple where both partners are carriers of the same genetic mutation (i.e. Cystic Fibrosis, Sickle Cell Disease, Fragile X Syndrome, Spinal Muscular Atrophy, etc). This is why MCRM recommends genetic carrier screening for our patients prior to undergoing any fertility treatment care.
- Recurrent Miscarriage
An estimated 70% of miscarriages is a result of chromosomal abnormality of the fetus
- Previous ART Failure