Sperm Selection

Selecting The Perfect Sperm = Higher Pregnancy Rates

It is well understood it takes a “good” sperm and “good” egg to produce a healthy embryo. Unfortunately, while scientific steps are being gradually made, we cannot, today, easily evaluate the quality of one’s eggs. This requires the utmost attention to be provided to selecting the highest quality sperm for usage with In Vitro Fertilization (IVF). Multiple studies have proven that sperm quality has a direct impact on early and late embryo development. The Missouri Center for Reproductive Medicine is utilizing multiple innovative and unique techniques to select the “best” sperm. The combined techniques are not only improving the selection process but also leading to increased pregnancy rates.

So how does one find the needle in the haystack with the “haystack” simply the entire ejaculate specimen and the “needle” the “good” sperm?

Utilizing a combination of techniques including a new and unique approach now available at MCRM:

ICSI and IMSI Processes

It is well understood it takes a “good” sperm and “good” egg to produce a healthy embryo. Unfortunately, while scientific steps are being gradually made, we cannot, today, easily evaluate the quality of one’s eggs. This requires the utmost attention to be provided to selecting the highest quality sperm for usage with In Vitro Fertilization (IVF). Multiple studies have proven that sperm quality has a direct impact on early and late embryo development. The Missouri Center for Reproductive Medicine is utilizing multiple innovative and unique techniques to select the “best” sperm. The combined techniques are not only improving the selection process but also leading to increased pregnancy rates.

So how does one find the needle in the haystack with the “haystack” simply the entire ejaculate specimen and the “needle” the “good” sperm?

Utilizing a combination of techniques including a new and unique approach now available at MCRM:

Magnetic Nanobead Selection Process

Today, the MCRM lab team has a new tool available assisting in reducing the size of the “haystack”. In Spring 2015, MCRM began to utilize a unique technique that filters a semen sample through the use of Magnetic-Activated Cell Sorting (MACS). The process begins with the addition of magnetic nanobeads to a semen sample. The beads will attach to a sperm whenever particular proteins are present on the surface of the sperm cell. These proteins are early indicators of decay for the particular sperm leading to an identifier for poor quality. When the sample of sperm and beads is filtered through a magnetic funnel, those sperm with attached beads are pulled away towards the magnetic surface and only the “purest, high-quality” sperm filter through. This new “haystack” is then utilized for the IMSI process and increases the likelihood of only the BEST sperm being selected and utilized. A 75% pregnancy rate has been experienced for those patients who have chosen to utilize this technique.

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Preselective Intracytoplasmic Sperm Injection (PICSI)

A Positive Sperm Selection Process

Preselective Intracytoplasmic Sperm Injection (PICSI) is a technique that simulates the natural selection of mature sperm post Nanobead Sperm Selection for the process of ICSI.  In natural conception, the fertilization of an oocyte only occurs by a sperm that is capable of binding to hyaloronan present on the surface of the oocyte. This interaction can only be achieved by a mature sperm.  Hyaluronan is a compound found naturally in the reproductive tract, as well as, other areas of the body and specifically in connecting cells of an oocyte.

The PICSI method includes the addition of small droplets of hyaluronan to a sample of sperm. The sperm that attaches to the hyaluronan is then selected for use in ICSI.

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17300 N. Outer Forty
Suite 101
Chesterfield, MO 63005

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636.778.9899