Embryo Genetic Testing (PGT-M/PGT-A)
For patients interested in knowing the genetic viability of an embryo prior to embryo transfer, MCRM Fertility offers patients pre-implantation genetic testing (PGT). This testing determines whether an embryo is genetically “normal” by investigating the DNA within. This may be done through one of two processes:
- Preimplantation Genetic Testing for Monogenic/Single Gene Defects (PGT-M) previously referred to as PGD
- Preimplantation Genetic Testing for Aneuploidies (PGT-A) Previously referred to as PGS
PGT-M is rationally used for patients who have a family history of genetic abnormalities such as cystic fibrosis, fragile X syndrome, Tay-Sachs disease, Duchenne Muscular Dystrophy, etc. or inherited cancer syndrome. PGT-M allows for selection of embryos that do not contain the specific genetic mutation for which the test is completed. The draw back to this analysis is that it does not look at the entire set of chromosomes for the specific embryo.
PGT-A is genetic testing where by, similar to PGT-M, DNA is extracted from the biopsied cells of an embryo and analyzed. Unlike PGT-M; however, PGT-A analyzes the entire set of chromosomes to ensure that there are the correct number are present. Along with the correct number of chromosomes, PGT-A also ensures there is the correct balance of chromosome sets; ensuring the patients the genetic integrity of the specific embryo.
A Patient Who Might Consider PGT-A
- Advanced Maternal Age
- History of Recurrent Miscarriages
- Previous ART Failure
- Male Factor with Low Sperm Concentration
- Previous Pregnancies with Chromosomal Abnormality