Embryo Genetic Testing

Embryo Genetic Testing (PGT-M/PGT-A) provides insight into the genetic health of embryos before the critical embryo transfer stage. Our Preimplantation Genetic Testing (PGT) services offer two distinct approaches: PGT-M, for individuals with a family history of specific genetic disorders, and PGT-A, designed to comprehensively assess the chromosomal health of embryos.

PGT-M assists in avoiding embryos carrying particular genetic mutations, while PGT-A ensures the overall genetic integrity and chromosomal balance, making it an essential consideration for patients facing various fertility challenges such as advanced maternal age, recurrent miscarriages, or previous ART failures.

Embryo Genetic Testing (PGT-M/PGT-A)

For patients interested in knowing the genetic viability of an embryo prior to embryo transfer, MCRM Fertility offers patients pre-implantation genetic testing (PGT). This testing determines whether an embryo is genetically “normal” by investigating the DNA within. This may be done through one of two processes:

  • Preimplantation Genetic Testing for Monogenic/Single Gene Defects (PGT-M) previously referred to as PGD
  • Preimplantation Genetic Testing for Aneuploidies (PGT-A) Previously referred to as PGS

PGT-M is rationally used for patients who have a family history of genetic abnormalities such as cystic fibrosis, fragile X syndrome, Tay-Sachs disease, Duchenne Muscular Dystrophy, etc. or inherited cancer syndrome. PGT-M allows for selection of embryos that do not contain the specific genetic mutation for which the test is completed. The draw back to this analysis is that it does not look at the entire set of chromosomes for the specific embryo.

PGT-A is genetic testing, similar to PGT-M, where DNA is extracted from the biopsied cells of an embryo and analyzed. Unlike PGT-M; however, PGT-A analyzes the entire set of chromosomes to ensure that the correct number is present.  Along with the correct number of chromosomes, PGT-A also ensures there is the correct balance of chromosome sets; ensuring the patients the genetic integrity of the specific embryo.

When to Consider PGT-A

  • Advanced Maternal Age
  • History of Recurrent Miscarriages
  • Previous ART Failure
  • Male Factor with Low Sperm Concentration
  • Previous Pregnancies with Chromosomal Abnormality
  • Gender Selection