The Importance of Using Time-Lapse Incubators such as the EmbryoScope in IVF
Research continues to show the importance of why Time-lapse monitoring of developing embryos in the context of IVF. A recent study published online in 2017 investigated the relationship between the physical parameters of metaphase II (MII) oocytes (eggs) with morphokinetic variables (physical attributes) of embryos post ICSI for use in IVF. The study reviewed 334 embryos using time-lapse monitoring in order to evaluate key developmental stages such as:
- Time to Second Polar Body
- Time to 2-cells, 3-cells, 4-cells, 5-cells, 6-cells, 7-cells and 8-cells
- Cleavage Patterns (including unevenness, reverse cleavage, and direct cleavage)
The research discovered that 79% of the eggs that fertilized normally had embryos develop with at least one abnormal physical characteristic. They concluded, the ability to view the embryo’s early stages of development using time-lapse monitoring showed evidence of a relationship between the quality of MII oocytes and the cleavage patterns of resulting embryos. The recommendation was made for the use of time-lapse monitoring within assisted reproductive programs.
At MCRM Fertility, we have seen similar results and agree with the findings of this research. We highly recommend that patients who chose to utilize IVF as their treatment that they should request the use of the available EmbryoScope time-lapse monitoring systems even if they also chose to utilize PGS evaluation.
Azita Faramarzi, Mohammad Ali Khalili and Sareh Ashourzadeh (2017). Oocyte morphology and embryo morphokinetics in an intra-cytoplasmic sperm injection programme. Is there a relationship? Cambridge University Press