New Biological Marker in DNA Damaged Sperm for Repeated Miscarriages

New research published in Clinical Chemistry, has linked repeated miscarriages to sperm with more DNA damage. 

Three or more miscarriages before 20 weeks of gestation defined repeated miscarriages and occurred in 1% to 2% of couples.  Customarily, the focus is on the women when screening for the underlying cause.  The spotlight in recent years has transferred from the mother to the father.  While the root of diminished sperm quality proves challenging to identify, there does appear to be a link to previously unexplained miscarriages.

Sperm health is acknowledged progressively as a vital factor in a healthy pregnancy, indicating that screening is essential for both partners.  In this particular study, 50 men whose partners had repeated miscarriages and 63 men whose partners did not have miscarriages, had their sperm DNA damage, semen reactive oxygen species (ROS), and hormone levels measured.  New biological markers were identified in the sperm of men whose partners had reoccurring miscarriages.   

The repeated miscarriage group, compared to healthy men had lower estradiol, and 15% to 16% lower levels of testosterone, in addition to decreased motility and irregular looking sperm.  Other noteworthy factors in the same group included significantly higher reactive oxygen species, men who were slightly more overweight, and older (37 vs. 30 in the non-miscarriages group). 

Considering this is a small study, further investigation will evaluate whether hormonal therapy, dietary or lifestyle changes affect ROS and hormone levels in men and fertility.  Conventionally, male infertility screening comprises of simple semen scrutiny and the measurement of hormones.  If hormone levels are low, a treatment option may be hormone therapy, although there could be unwanted effects — advanced testing for otherwise ambiguous cases of infertility has been suggested.

Many studies have researched the parallel between lower sperm DNA damage and increased antioxidant supplements, such as E and C.  Clinical trials have tested the outcome of these supplements and have proved favorable.  Nonetheless, there have been conflicting results and caution should be exhibited.

This new information is a perfect example of why MCRM Fertility pioneered the use of nanobead sperm selection to remove the DNA damaged sperm from a sample for use in IVF.   Let MCRM help with your fertility needs and schedule your consultation today!