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Can Low-Dose Aspirin Affect Pregnancy Outcomes?

According to the results of a recent study, (LDA) or low-dose aspirin therapy before conception may enhance pregnancy outcomes for women who have experienced miscarriage.

Reproduction can be a clumsy process, with the chance of conception thought to be about 25% per menstrual cycle.  Nearly 30% of clinically recognized pregnancies end in loss.  Additionally, the possibility of spontaneous pregnancy loss grows along with the number of pregnancy losses.

The most common cause of loss is aneuploidy, but others include uterine anomalies, antiphospholipid antibody syndrome, and inadequately controlled endocrine disorders like diabetes.  Although the main culprit of loss in euploid pregnancies is unknown in most cases, one key driver is inflammation causing decreased blood flow to the reproductive tract.

Researchers used the EAGeR (Effects of Aspirin on Gestation and Reproduction) trial to build a prospective cohort for a post-hoc analysis.  Included were 1,227 U.S. women between the ages of 18 and 40 who were attempting pregnancy and had 1 or 2 previous pregnancy losses.  Each participant was either given a placebo or a daily low-dose aspirin (81 milligrams), and adherence to the protocol was monitored.

For every 100 women in the trial, relative to placebo, adhering to LDA for 5 of 7 days per week led to 8 more hCG-detected pregnancies, 15 more live births, and 6 fewer pregnancy losses.  On top of that, results indicated a reduction in the likely effects in those who began LDA therapy post-conception.

“Per protocol results suggest that preconception use of LDA at least 4 days per week may improve reproductive outcomes for women who have had 1 or 2 pregnancy losses,” the authors concluded. “Increasing adherence to daily LDA seems to be key to improving effectiveness.”

This study’s trial data was considered observational and are subject to the limitations of prospective observational studies.

As always, MCRM Fertility strives to keep you at the forefront of new information as it becomes available. Our team is here to support you and answer any questions or concerns you may have. Please consider us your partner along your journey to fertility.