IVF laboratory ICSI microscope and display of an embryo biopsy for PGT-A

Preimplantation Genetic Testing for Aneuploidy and Diminished Ovarian Reserve

By: Mira Aubuchon, MD

During in vitro fertilization, we have the capability of safely performing preimplantation testing for aneuploidy (PGT-A) genetic testing on a small sample of the cells from the future placenta from each embryo that has reached the blastocyst stage, an advanced stage of development.  PGT-A results indicate whether any of the chromosomes are missing or duplicated or thereby “aneuploid”, which typically leads to unsuccessful outcomes and is commonly found as women age.  However, PGT-euploid embryos, which have a healthy number of chromosomes, perform similarly regardless of age.  Thus, PGT-A is a powerful tool particularly in women in their mid to late 30s or otherwise higher age.  

Jaswa et al in Fertility and Sterility reported that diminished ovarian reserve (DOR) was also a risk factor for embryo aneuploidy, regardless of age.  Therefore, patients undergoing IVF with DOR diagnosed by low antimullerian hormone (AMH), elevated follicle stimulating hormone (FSH), or low ultrasound antral follicle counts (AFC) may also benefit from PGT-A regardless of age; because this is a diagnosis where time is of the essence.  For example, in the event too few follicles are retrieved and/or an unfavorable PGT report is returned, patients can proceed with another egg retrieval in a timelier manner. 

If you would like to learn more about PGT-A or your fertility prognosis, schedule a consultation with one of the MCRM Fertility specialists, Today!

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