Enhanced Sperm Testing: Examining DNA Fragmentation

Another piece of diagnostic information that has gained validity over the last decade is that of DNA Fragmentation as it correlates to fertilization. Semen Analysis Testing with DNA Fragmentation testing is completed by adding a fluorescent dye to any sperm that have stored, within itself, DNA that is either not properly packaged or is damaged. The percentage of damaged or fragmented sperm DNA is directly correlated to that sperm's ability to fertilize an egg under natural conditions. The higher the percentage of fragmentation the less likely that particular sperm would have to properly fertilize an egg. Therefore, leading to an increased risk for miscarriage, early pregnancy loss, embryo failure and/or implantation failure.

The combination of a magnified semen analysis (MSA) with DNA Fragmentation can help both the physician and patient determine the best course of action. That is why the Missouri Center for Reproductive Medicine (MCRM), through the Center for Male Infertility, offers both the human reviewed magnified semen analysis and Semen DNA Fragmentation testing in order to provide patients the most complete picture of the male fertility factor. Ultimately, the use of these tests, combined, help provide patients with answers on why they may be having difficulty conceiving and how they may still be able to have a family through the assistance of the caring staff at MCRM.


17300 N. Outer Forty
Suite 101
Chesterfield, MO 63005

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