Chaos In The Embryo: Genetics + Fertility = Outcome

Recent literature and studies have shown that through the use of chromosomal assessment , human embryos are even more unstable than previously thought. An analysis of embryos derived from fertility treatments, reveals the high rate of abnormalities in these embryos. It has been well known for a long time that high rates of chromosomal abnormality occur in human eggs which leads to chromosomal abnormalities (aneuploidy) in embryos. Chromosomal aneuploidy is associated with recurrent pregnancy loss, early pregnancy loss, implantation failure after IVF or otherwise natural conception, and recurrent IVF failure.

It has previously been postulated that immunologic abnormalities play a significant role but it is clear with these new studies, especially by Vanneste et al., that indeed embryonic abnormalities are far and away the most important role player in recurrent pregnancy loss and ART failure. So, clearly the factors involving natural killer cells are not at all a primary cause of IVF failure, implantation failure, etc. It is far and away known, now, that embryonic abnormalities are critical and the issue that needs to be addressed. The traditional therapy for natural killer cells, Intralipids infusion, certainly does not improve live birth rates as previously thought, for example.

Microarray-based technologies, such as Next Generation Sequencing , show that structural abnormalities occur at a shockingly high rate in embryos. Roughly 1 in 10 embryos have a normal compliment as determined in this study by Vanneste. As a result of this and other recent research, at the MCRM Fertility (MCRM Fertility), we have embarked upon a new approach for doing in vitro fertilization and certainly a new approach for ICSI to ensure the healthiest, chromosomally normal embryos are achieved. This includes the usage of MCRM’s exclusive Nanobead Sperm Selection techniques which have shown to improve the aneuploidy rate in embryos. This is done by ensuring the sperm utilized for fertilization have the highest genetic integrity yielding a higher chance for healthy embryo development. Traditionally, the cost to assess the genetic integrity of human embryos has been too costly for most patients. However, MCRM is working with one of the nation’s premier genetics labs to not only provide the most advanced testing methodology available but also the ability to substantially lower the related costs making it more affordable for the majority. Thus, if you are able to reduce the aneuploidy rate by sperm selection and improve the detection of aneuploidy in embryos with the genetic assessment that we have, we are able to overall significantly improve the live birth rate. This improves the overall efficiency of the IVF process and again lowers overall cost. MCRM provides the lowest cost, highest value IVF in the area and efficiently improves live birth rates at the same time. Additionally, recurrent implantation failure and/or pregnancy loss are all reduced as well. It starts with the embryo and we effectively are able to address these things most efficiently and cost effectively.

We do recognize, occasionally, endometrium/lining-related problems are a factor to recurrent pregnancy loss and ART failure, as well, thus we have adopted, in such cases ,being able to diagnose and treat endometrial-related problems with frozen embryo transfer (FET) versus fresh embryo transfer. Again, recent research has shown by completing the the proper assessment of the endometrium and the use of FET the overall result is an increase in the live birth rate. As highlighted to previously, natural killer cell testing is a thing of the past in the vast majority of patients and really is not an effective tool due to its high false-positive rate. All in all, the key is the assessment of the overall health of the embryo and the lining with the latest available techniques.

If you suffer from recurrent miscarriage/pregnancy loss or have had priory IVF failure, please feel free to contact me or request to schedule an initial consultation. I encourage you to discuss these things with me and how, together, we can address your individual situation and in turn bring your dreams to life.

Sincerely and regards,

Peter Ahlering, M.D.