Intralipid Usage: Does It Improve IVF Pregnancy Outcomes?

On many occasions, when a new patient arrives at MCRM Fertility seeking assistance it is because they have either tried advanced fertility treatments elsewhere without success, have had multiple miscarriages, been told they have ” unexplained infertility” or a combination of these. Due to their prior circumstances, in many cases, the patient was previously advised to have natural killer (NK) cell testing completed. All too often, as a result of flawed testing, the results returned said NK Cells were the cause of the patient’s difficulty in becoming pregnant and/or staying pregnant. The next step, utilize intralipid infusion with the patient’s next IVF treatment. Several recent studies have already shown that the testing utilized for NK Cell screening has many flaws; so, should intralipids be recommended in the first place and secondly does the use of intralipids have any positive impact on pregnancy outcomes?

In the August 30, 2016, International Journal of Gynecology & Obstetrics , a recent study was published that investigated, scientifically, the usage of intralipids to improve pregnancy outcomes for patients with recurrent miscarriage and/or natural killer cell activity, ” Intralipid supplementation in women with recurrent spontaneous abortion and elevated levels of natural killer cells“. The double-blinded, random study took place for two years (2013-2015) in Egypt and investigated 296 women with “unexplained” secondary infertility, elevated natural killer cells and recurrent miscarriage loss. Patients were randomly selected and given either intralipid or saline infusion on the day of the patients egg retrieval procedure. A second infusion was given to the patients within a week after an initial positive pregnancy and continuing every two weeks thereafter through the patient’s first trimester. The end result, intralipid supplementation DID NOT increase the frequency of chemical pregnancy.