Lab equipment centrifuging blood. Concept image of a blood test.3d rendering.Lab equipment centrifuging blood. Concept image of a blood test.3d rendering.

Effects of Platelet-rich Plasma in Treatment of Thin Endometrium

Successful implantation requires a high-quality embryo and sufficient receptive endometrial growth. During implantation, the human endometrium goes through extraordinary changes that are crucial for endometrial and embryonic development. Because of this, it has been essential for clinicians to be sure that the endometrial thickness (ET) and embryo quality are measured or treated in case of deficiencies. Several strategies have been used to increase the endometrial thickness and its quality for embryo transfer, including low dose Aspirin, estrogen, vaginal sildenafil, and more. Unfortunately, not all cases with thin endometrium show improvement with these strategies.

A new treatment for thin endometrium is Platelet-rich Plasma (PRP). Platelet-rich plasma, also known as autologous conditioned plasma, is a concentrate of platelet-rich plasma protein derived from whole blood, centrifuged to remove red blood cells. PRP is prepared from the patient’s blood and contains a number of growth factors and cytokines.  

Note from Peter Ahlering, M.D., Medical Director

“Refractory thin endometrium is a major issue for some patients. When the lining is thin, it is associated with a lower probability of pregnancy. For several decades we have struggled with many different therapeutic options to try and improve the refractory endometrium. It is a source of much consternation and frustration as many treatments have come and gone, and none has proven successful in the end for most patients. This is where PRP may be beneficial for many in this difficult situation. We have had success with us at MCRM fertility and include this in our repertoire of patients’ options in this situation. It is an easy and reasonable expense at MCRM.

In patients with implantation failure, this particular treatment may also be a consideration depending upon the case… It’s always something to know about and discuss. We have a protocol in place for utilizing this, and if applicable, it may be something of interest to couples.”

As always, MCRM Fertility strives to keep you at the forefront of new information as it becomes available. Our team is here to support you and answer any questions or concerns you may have. Read the full review here.